Overview
Tirzepatide is a dual GIP/GLP-1 receptor agonist that provides even greater weight loss than semaglutide alone. It's the newest generation of incretin-based therapies, showing unprecedented results in clinical trials.
How It Works
Tirzepatide activates both GIP and GLP-1 receptors, providing synergistic effects on appetite suppression, insulin secretion, and glucose metabolism. The dual action leads to greater efficacy than single-receptor agonists.
Research Status
FDA approved as Mounjaro (diabetes) and Zepbound (obesity). SURMOUNT trials showed 20%+ weight loss.
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Semaglutide is a GLP-1 receptor agonist that mimics the incretin hormone GLP-1, which is released after eating. It's one of the most effective peptides for weight loss and blood sugar control, FDA-approved for diabetes and obesity treatment.
AOD-9604
AOD-9604 is a synthetic 16-amino acid peptide fragment derived from the C-terminal portion of human growth hormone (amino acids 176-191). It was developed to harness growth hormone's lipolytic (fat-burning) properties without affecting blood sugar or growth.
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Tesamorelin is a synthetic 44-amino acid GHRH (Growth Hormone Releasing Hormone) analog with enhanced stability. It is the only FDA-approved peptide for reducing visceral adipose tissue, originally developed for HIV-associated lipodystrophy.