KPV
Buy NowAlso known as: Lysine-Proline-Valine, α-MSH Fragment
Overview
KPV is a tripeptide (Lysine-Proline-Valine) derived from alpha-melanocyte stimulating hormone (α-MSH). It exhibits potent anti-inflammatory effects, particularly in the gut, without the tanning or sexual side effects of other α-MSH derivatives.
How It Works
KPV inhibits the activation of NF-κB and MAP kinase inflammatory pathways at nanomolar concentrations. It reduces pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) by interacting with melanocortin receptors on immune and epithelial cells. Unlike other anti-inflammatory drugs, it doesn't suppress immune function.
Research Status
Preclinical research only. Promising studies in colitis models. Not FDA approved. Published research available (PMC2431115).
Related Peptides
BPC-157
BPC-157 is a synthetic peptide derived from a protein found in stomach acid. It's known for its remarkable healing properties, particularly for muscles, tendons, and the digestive system.
LL-37
LL-37 is the only human cathelicidin antimicrobial peptide, a 37-amino acid cationic peptide derived from hCAP18. It exhibits broad-spectrum antimicrobial activity against bacteria, viruses, and fungi while modulating immune responses and promoting wound healing.
Related Peptides
BPC-157
BPC-157 is a synthetic peptide derived from a protein found in stomach acid. It's known for its remarkable healing properties, particularly for muscles, tendons, and the digestive system.
LL-37
LL-37 is the only human cathelicidin antimicrobial peptide, a 37-amino acid cationic peptide derived from hCAP18. It exhibits broad-spectrum antimicrobial activity against bacteria, viruses, and fungi while modulating immune responses and promoting wound healing.