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Kisspeptin

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Also known as: Kisspeptin-10, KP-10, Metastin

Overview

Kisspeptin is a hormone that regulates the reproductive system by stimulating GnRH release. It plays a crucial role in puberty onset, fertility, and has emerging applications in treating low libido and reproductive disorders.

How It Works

Kisspeptin binds to the GPR54 receptor in the hypothalamus, triggering the release of GnRH. This upstream regulation affects the entire HPG axis, stimulating LH and FSH release and subsequently testosterone/estrogen production.

Research Status

Emerging therapeutic. Multiple clinical trials showing promise for reproductive disorders and libido. Not yet FDA approved.